Articles with public access mandates - Mitsuhiko Ikura - Canadian Cancer SocietyLearn more
Not available based on mandate: 3
Integrated RAS signaling defined by parallel NMR detection of effectors and regulators
MJ Smith, M Ikura
Nature chemical biology 10 (3), 223-230, 2014
NMR in integrated biophysical drug discovery for RAS: Past, present, and future
CB Marshall, F KleinJan, T Gebregiworgis, KY Lee, Z Fang, BJ Eves, ...
Journal of Biomolecular NMR 74, 531-554, 2020
The Self‐Association of the KRAS4b Protein is Altered by Lipid‐Bilayer Composition and Electrostatics
KY Lee, M Ikura, CB Marshall
Angewandte Chemie 135 (18), e202218698, 2023
Available based on mandate: 23
Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site
MT Mazhab-Jafari, CB Marshall, MJ Smith, GMC Gasmi-Seabrook, ...
Proceedings of the National Academy of Sciences 112 (21), 6625-6630, 2015
Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation
Y Kano, T Gebregiworgis, CB Marshall, N Radulovich, BPK Poon, ...
Nature communications 10 (1), 224, 2019
Inhibition of K-RAS4B by a unique mechanism of action: stabilizing membrane-dependent occlusion of the effector-binding site
Z Fang, CB Marshall, T Nishikawa, AD Gossert, JM Jansen, W Jahnke, ...
Cell chemical biology 25 (11), 1327-1336. e4, 2018
Two distinct structures of membrane‐associated homodimers of GTP‐and GDP‐bound KRAS4B revealed by paramagnetic relaxation enhancement
KY Lee, Z Fang, M Enomoto, G Gasmi‐Seabrook, L Zheng, S Koide, ...
Angewandte Chemie International Edition 59 (27), 11037-11045, 2020
Real-time NMR monitoring of biological activities in complex physiological environments
MJ Smith, CB Marshall, FX Theillet, A Binolfi, P Selenko, M Ikura
Current opinion in structural biology 32, 39-47, 2015
MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity
MJ Sandí, CB Marshall, M Balan, É Coyaud, M Zhou, DM Monson, ...
Science signaling 10 (503), eaan3286, 2017
Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane
Z Fang, KY Lee, KG Huo, G Gasmi-Seabrook, L Zheng, N Moghal, ...
Proceedings of the National Academy of Sciences 117 (22), 12101-12108, 2020
α-Catenin phosphorylation promotes intercellular adhesion through a dual-kinase mechanism
DJ Escobar, R Desai, N Ishiyama, SS Folmsbee, MN Novak, AS Flozak, ...
Journal of cell science 128 (6), 1150-1165, 2015
The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors
T Gebregiworgis, Y Kano, J St-Germain, N Radulovich, ML Udaskin, ...
Nature communications 12 (1), 6274, 2021
Evolution of AF6-RAS association and its implications in mixed-lineage leukemia
MJ Smith, E Ottoni, N Ishiyama, M Goudreault, A Haman, C Meyer, ...
Nature Communications 8 (1), 1099, 2017
Real-time in-cell NMR reveals the intracellular modulation of GTP-bound levels of RAS
Q Zhao, R Fujimiya, S Kubo, CB Marshall, M Ikura, I Shimada, N Nishida
Cell Reports 32 (8), 2020
Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR)
MT Mazhab-Jafari, CB Marshall, J Ho, N Ishiyama, V Stambolic, M Ikura
Journal of Biological Chemistry 289 (18), 12195-12201, 2014
Calmodulin disrupts plasma membrane localization of farnesylated KRAS4b by sequestering its lipid moiety
BMM Grant, M Enomoto, SI Back, KY Lee, T Gebregiworgis, N Ishiyama, ...
Science Signaling 13 (625), eaaz0344, 2020
A Ca2+-dependent mechanism of neuronal survival mediated by the microtubule-associated protein p600
C Belzil, G Neumayer, AP Vassilev, KL Yap, H Konishi, S Rivest, ...
Journal of Biological Chemistry 288 (34), 24452-24464, 2013
Lung cancer driven by BRAFG469V mutation is targetable by EGFR kinase inhibitors
KG Huo, H Notsuda, Z Fang, NF Liu, T Gebregiworgis, Q Li, NA Pham, ...
Journal of Thoracic Oncology 17 (2), 277-288, 2022
Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine–dependent interface: a model for KRAS oligomerization
KY Lee, M Enomoto, T Gebregiworgis, GMC Gasmi-Seabrook, M Ikura, ...
Chemical Science 12 (38), 12827-12837, 2021
Biochemical classification of disease-associated mutants of RAS-like protein expressed in many tissues (RIT1)
Z Fang, CB Marshall, JC Yin, MT Mazhab-Jafari, GMC Gasmi-Seabrook, ...
Journal of Biological Chemistry 291 (30), 15641-15652, 2016
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