Articles with public access mandates - Matthieu Schapira - Canadian Institutes of Health ResearchLearn more
NoteFor this mandate, articles should be available from specific locations.
Not available based on mandate: 13
Epigenetic protein families: a new frontier for drug discovery
CH Arrowsmith, C Bountra, PV Fish, K Lee, M Schapira
Nature reviews Drug discovery 11 (5), 384-400, 2012
Protein arginine methylation: from enigmatic functions to therapeutic targeting
Q Wu, M Schapira, CH Arrowsmith, D Barsyte-Lovejoy
Nature reviews Drug discovery 20 (7), 509-530, 2021
Structure-based optimization of a small molecule antagonist of the interaction between WD repeat-containing protein 5 (WDR5) and mixed-lineage leukemia 1 (MLL1)
M Getlik, D Smil, C Zepeda-Velazquez, Y Bolshan, G Poda, H Wu, A Dong, ...
Journal of medicinal chemistry 59 (6), 2478-2496, 2016
Structural chemistry of the histone methyltransferases cofactor binding site
V Campagna-Slater, MW Mok, KT Nguyen, M Feher, R Najmanovich, ...
Journal of chemical information and modeling 51 (3), 612-623, 2011
Druggability of methyl-lysine binding sites
C Santiago, K Nguyen, M Schapira
Journal of computer-aided molecular design 25, 1171-1178, 2011
A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity
A Allali-Hassani, GA Wasney, I Chau, BS Hong, G Senisterra, P Loppnau, ...
Biochemical Journal 424 (1), 15-26, 2009
Structural genomics and drug discovery: all in the family
J Weigelt, LDB McBroom-Cerajewski, M Schapira, Y Zhao, ...
Current opinion in chemical biology 12 (1), 32-39, 2008
Pharmacophore screening of the protein data bank for specific binding site chemistry
V Campagna-Slater, AG Arrowsmith, Y Zhao, M Schapira
Journal of chemical information and modeling 50 (3), 358-367, 2010
Discovery of indoline-based, natural-product-like compounds as probes of focal adhesion kinase signaling pathways
RR Poondra, NN Kumar, K Bijian, M Prakesch, V Campagna-Slater, ...
Journal of combinatorial chemistry 11 (2), 303-309, 2009
Finding inspiration in the protein data bank to chemically antagonize readers of the histone code
V Campagna‐Slater, M Schapira
Molecular Informatics 29 (4), 322-331, 2010
Evaluation of virtual screening as a tool for chemical genetic applications
V Campagna-Slater, M Schapira
Journal of chemical information and modeling 49 (9), 2082-2091, 2009
Crystal structures of Klebsiella pneumoniae pantothenate kinase in complex with N‐substituted pantothenamides
B Li, W Tempel, D Smil, Y Bolshan, M Schapira, HW Park
Proteins: Structure, Function, and Bioinformatics 81 (8), 1466-1472, 2013
Building skeletally diverse architectures on the Indoline Scaffold: The discovery of a chemical probe of focal adhesion kinase signaling networks
M Prakesch, K Bijian, V Campagna-Slater, S Quevillon, R Joseph, ...
Bioorganic & medicinal chemistry 16 (21), 9596-9602, 2008
Available based on mandate: 33
Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation
DB Yap, J Chu, T Berg, M Schapira, SWG Cheng, A Moradian, RD Morin, ...
Blood, The Journal of the American Society of Hematology 117 (8), 2451-2459, 2011
Recognition and specificity determinants of the human cbx chromodomains
L Kaustov, H Ouyang, M Amaya, A Lemak, N Nady, S Duan, GA Wasney, ...
Journal of Biological Chemistry 286 (1), 521-529, 2011
Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity
A Schuetz, J Min, A Allali-Hassani, M Schapira, M Shuen, P Loppnau, ...
Journal of Biological Chemistry 283 (17), 11355-11363, 2008
Structural biology of human H3K9 methyltransferases
H Wu, J Min, VV Lunin, T Antoshenko, L Dombrovski, H Zeng, ...
PloS one 5 (1), e8570, 2010
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors
W Yu, EJ Chory, AK Wernimont, W Tempel, A Scopton, A Federation, ...
Nature communications 3 (1), 1288, 2012
WD40 repeat domain proteins: a novel target class?
M Schapira, M Tyers, M Torrent, CH Arrowsmith
Nature reviews Drug discovery 16 (11), 773-786, 2017
(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells
D Barsyte-Lovejoy, F Li, MJ Oudhoff, JH Tatlock, A Dong, H Zeng, H Wu, ...
Proceedings of the National Academy of Sciences 111 (35), 12853-12858, 2014
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