Articles with public access mandates - Mitsuhiko Ikura - Heart and Stroke Foundation of CanadaLearn more
Available based on mandate: 19
STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation
M Muik, M Fahrner, R Schindl, P Stathopulos, I Frischauf, I Derler, P Plenk, ...
The EMBO journal 30 (9), 1678-1689, 2011
Initial activation of STIM1, the regulator of store-operated calcium entry
Y Zhou, P Srinivasan, S Razavi, S Seymour, P Meraner, A Gudlur, ...
Nature structural & molecular biology 20 (8), 973-981, 2013
Structural and functional conservation of key domains in InsP3 and ryanodine receptors
MD Seo, S Velamakanni, N Ishiyama, PB Stathopulos, AM Rossi, ...
Nature 483 (7387), 108-112, 2012
A coiled-coil clamp controls both conformation and clustering of stromal interaction molecule 1 (STIM1)
M Fahrner, M Muik, R Schindl, C Butorac, P Stathopulos, L Zheng, I Jardin, ...
Journal of Biological Chemistry 289 (48), 33231-33244, 2014
Cholesterol modulates Orai1 channel function
I Derler, I Jardin, PB Stathopulos, M Muik, M Fahrner, V Zayats, ...
Science signaling 9 (412), ra10-ra10, 2016
Structural insights into endoplasmic reticulum stored calcium regulation by inositol 1, 4, 5-trisphosphate and ryanodine receptors
MD Seo, M Enomoto, N Ishiyama, PB Stathopulos, M Ikura
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1853 (9), 1980-1991, 2015
Missense mutation in immunodeficient patients shows the multifunctional roles of coiled-coil domain 3 (CC3) in STIM1 activation
M Maus, A Jairaman, PB Stathopulos, M Muik, M Fahrner, C Weidinger, ...
Proceedings of the National Academy of Sciences 112 (19), 6206-6211, 2015
Calmodulin and STIM proteins: Two major calcium sensors in the cytoplasm and endoplasmic reticulum
CB Marshall, T Nishikawa, M Osawa, PB Stathopulos, M Ikura
Biochemical and biophysical research communications 460 (1), 5-21, 2015
Tyr-167/Trp-168 in type 1/3 inositol 1, 4, 5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening
H Yamazaki, J Chan, M Ikura, T Michikawa, K Mikoshiba
Journal of Biological Chemistry 285 (46), 36081-36091, 2010
Structural studies of inositol 1, 4, 5-trisphosphate receptor: coupling ligand binding to channel gating
J Chan, H Yamazaki, N Ishiyama, MD Seo, TK Mal, T Michikawa, ...
Journal of Biological Chemistry 285 (46), 36092-36099, 2010
Structural determination of the phosphorylation domain of the ryanodine receptor
P Sharma, N Ishiyama, U Nair, W Li, A Dong, T Miyake, A Wilson, T Ryan, ...
The FEBS journal 279 (20), 3952-3964, 2012
Structural aspects of calcium-release activated calcium channel function
PB Stathopulos, M Ikura
Channels 7 (5), 344-353, 2013
Type 2 ryanodine receptor domain A contains a unique and dynamic α-helix that transitions to a β-strand in a mutant linked with a heritable cardiomyopathy
FJ Amador, L Kimlicka, PB Stathopulos, GMC Gasmi-Seabrook, ...
Journal of Molecular Biology 425 (21), 4034-4046, 2013
Themes and variations in ER/SR calcium release channels: structure and function
PB Stathopulos, M Seo, M Enomoto, FJ Amador, N Ishiyama, M Ikura
Physiology 27 (6), 331-342, 2012
Calmodulin disrupts plasma membrane localization of farnesylated KRAS4b by sequestering its lipid moiety
BMM Grant, M Enomoto, SI Back, KY Lee, T Gebregiworgis, N Ishiyama, ...
Science Signaling 13 (625), eaaz0344, 2020
A non-canonical calmodulin target motif comprising a polybasic region and lipidated terminal residue regulates localization
BMM Grant, M Enomoto, M Ikura, CB Marshall
International Journal of Molecular Sciences 21 (8), 2751, 2020
Conformational states of syntaxin-1 govern the necessity of N-peptide binding in exocytosis of PC12 cells and Caenorhabditis elegans
S Park, NR Bin, M Michael Rajah, B Kim, TC Chou, SA Kang, K Sugita, ...
Molecular Biology of the Cell 27 (4), 669-685, 2016
The p.E152K-STIM1 mutation deregulates Ca2+ signaling contributing to chronic pancreatitis
M Burgos, R Philippe, F Antigny, P Buscaglia, E Masson, S Mukherjee, ...
Journal of Cell Science 134 (3), jcs244012, 2021
Expression and purification of calmodulin for NMR and other biophysical applications
BMM Grant, CB Marshall, M Ikura
Calcium-Binding Proteins of the EF-Hand Superfamily: From Basics to Medical …, 2019
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