Authors
M Lourdes Sampietro, Stella Trompet, Jeffrey JW Verschuren, Rudolf P Talens, Joris Deelen, Bastiaan T Heijmans, Robbert J de Winter, Rene A Tio, Pieter AFM Doevendans, Santhi K Ganesh, Elizabeth G Nabel, Harm-Jan Westra, Lude Franke, Erik B van den Akker, Rudi GJ Westendorp, Aeilko H Zwinderman, Adnan Kastrati, Werner Koch, P Eline Slagboom, Peter de Knijff, J Wouter Jukema
Publication date
2011/12/1
Journal
Human molecular genetics
Volume
20
Issue
23
Pages
4748-4757
Publisher
Oxford University Press
Description
Percutaneous coronary intervention (PCI) has become an effective therapy to treat obstructive coronary artery diseases (CAD). However, one of the major drawbacks of PCI is the occurrence of restenosis in 5–25% of all initially treated patients. Restenosis is defined as the re-narrowing of the lumen of the blood vessel, resulting in renewed symptoms and the need for repeated intervention. To identify genetic variants that are associated with restenosis, a genome-wide association study (GWAS) was conducted in 295 patients who developed restenosis (cases) and 571 who did not (controls) from the GENetic Determinants of Restenosis (GENDER) study. Analysis of ∼550 000 single nucleotide polymorphisms (SNPs) in GENDER was followed by a replication phase in three independent case–control populations (533 cases and 3067 controls). A potential susceptibility locus for restenosis at chromosome 12 …
Scholar articles
ML Sampietro, S Trompet, JJW Verschuren, RP Talens… - Human molecular genetics, 2011