Authors
GH Dolmans, PM Werker, HC Hennies, D Furniss, EA Festen, L Franke, P van der Vlies, BH Wolffenbuttel, H Giele, RA Ophoff, C Wijmenga
Publication date
2011/5/1
Journal
Plastic and Reconstructive Surgery
Volume
127
Pages
27
Publisher
LWW
Description
Background:
Dupuytren's disease (DD) is a benign fibromatosis of the hand and fingers, often leading to disabling extension deficits of the finger joints. We hypothesize that the susceptibility to DD is influenced by multiple genetic and environmental factors. To identify DD susceptibility genes to further our understanding of the pathogenesis of DD, a genome-wide association study was performed.
Methods:
We performed a genome-wide association study in 960 Dutch DD cases and 3,117 controls. The top 35 associated single nucleotide polymorphisms (SNPs) were replicated in three independent replication sets, compromising 1,365 DD cases and 8,445 controls from Germany, the UK and the Netherlands.
Results:
We initially observed genome-wide significance for 8 SNPs at three loci. After replication and joint analysis of 2,325 DD cases and 11,562 controls 11 SNPs from 9 different loci showed genome-wide …
Scholar articles
GH Dolmans, PM Werker, HC Hennies, D Furniss… - Plastic and Reconstructive Surgery, 2011