Authors
Alexander Kurilshikov, Carolina Medina-Gomez, Rodrigo Bacigalupe, Djawad Radjabzadeh, Jun Wang, Ayse Demirkan, Caroline I Le Roy, Juan Antonio Raygoza Garay, Casey T Finnicum, Xingrong Liu, Daria V Zhernakova, Marc Jan Bonder, Tue H Hansen, Fabian Frost, Malte C Rühlemann, Williams Turpin, Jee-Young Moon, Han-Na Kim, Kreete Lüll, Elad Barkan, Shiraz A Shah, Myriam Fornage, Joanna Szopinska-Tokov, Zachary D Wallen, Dmitrii Borisevich, Lars Agreus, Anna Andreasson, Corinna Bang, Larbi Bedrani, Jordana T Bell, Hans Bisgaard, Michael Boehnke, Dorret I Boomsma, Robert D Burk, Annique Claringbould, Kenneth Croitoru, Gareth E Davies, Cornelia M van Duijn, Liesbeth Duijts, Gwen Falony, Jingyuan Fu, Adriaan van der Graaf, Torben Hansen, Georg Homuth, David A Hughes, Richard G Ijzerman, Matthew A Jackson, Vincent WV Jaddoe, Marie Joossens, Torben Jørgensen, Daniel Keszthelyi, Rob Knight, Markku Laakso, Matthias Laudes, Lenore J Launer, Wolfgang Lieb, Aldons J Lusis, Ad AM Masclee, Henriette A Moll, Zlatan Mujagic, Qi Qibin, Daphna Rothschild, Hocheol Shin, Søren J Sørensen, Claire J Steves, Jonathan Thorsen, Nicholas J Timpson, Raul Y Tito, Sara Vieira-Silva, Uwe Völker, Henry Völzke, Urmo Võsa, Kaitlin H Wade, Susanna Walter, Kyoko Watanabe, Stefan Weiss, Frank U Weiss, Omer Weissbrod, Harm-Jan Westra, Gonneke Willemsen, Haydeh Payami, Daisy MAE Jonkers, Alejandro Arias Vasquez, Eco JC de Geus, Katie A Meyer, Jakob Stokholm, Eran Segal, Elin Org, Cisca Wijmenga, Hyung-Lae Kim, Robert C Kaplan, Tim D Spector, Andre G Uitterlinden, Fernando Rivadeneira, Andre Franke, Markus M Lerch, Lude Franke, Serena Sanna, Mauro D’Amato, Oluf Pedersen, Andrew D Paterson, Robert Kraaij, Jeroen Raes, Alexandra Zhernakova
Publication date
2021/2
Journal
Nature genetics
Volume
53
Issue
2
Pages
156-165
Publisher
Nature Publishing Group US
Description
To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium curated and analyzed genome-wide genotypes and 16S fecal microbiome data from 18,340 individuals (24 cohorts). Microbial composition showed high variability across cohorts: only 9 of 410 genera were detected in more than 95% of samples. A genome-wide association study of host genetic variation regarding microbial taxa identified 31 loci affecting the microbiome at a genome-wide significant (P < 5 × 10−8) threshold. One locus, the lactase (LCT) gene locus, reached study-wide significance (genome-wide association study signal: P = 1.28 × 10−20), and it showed an age-dependent association with Bifidobacterium abundance. Other associations were suggestive (1.95 × 10−10 < P < 5 × 10−8) but enriched for taxa showing high heritability and for genes expressed in the intestine and brain. A …
Total citations
Scholar articles
A Kurilshikov, C Medina-Gomez, R Bacigalupe… - Nature genetics, 2021
A Kurilshikov, C Medina-Gomez, R Bacigalupe… - BioRxiv, 2020