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33 SINGLE CELL ANALYSIS OF GUT BIOPSY TISSUE REVEALS CELL TYPE-AND INFLAMMATION-SPECIFIC EXPRESSION QUANTATIVE TRAIT LOCI IN CROHN'S DISEASE Roy Oelen, Werna Uniken-Venema, Marjolein Dijkema, Emilia Bigaeva, Sofie de Jong, Maria Paraskevopoulou, Pratik Panchal, Xinghao Zhang, Eleonora A. Festen, Lude Franke, Monique G. Van der Wijst Genome-wide association studies have linked more than 320 genetic loci to IBD, however how these genetic risk factors lead to disease progression remains largely unknown. The advent of RNA-seq allowed us to link genetic variants to gene expression via expression Quantative Trait Loci (eQTLs), which have proven to be linked to disease phenotypes. The overlap between genetic variants that are linked to IBD, and the ones that affect gene expression unfortunately is quite poor. We hypothesize that this happens because cell …