Authors
Jürg Nussberger, Jean-François Aubert, Karima Bouzourene, Maxime Pellegrin, Daniel Hayoz, Lucia Mazzolai
Publication date
2008/5/1
Journal
Hypertension
Volume
51
Issue
5
Pages
1306-1311
Publisher
Lippincott Williams & Wilkins
Description
Hypertension is associated with increased risk of cardiovascular diseases. Antihypertensive treatment, particularly blockade of the renin-angiotensin system, contributes to prevent atherosclerosis-mediated cardiovascular events. Direct comparison of different antihypertensive treatments on atherosclerosis and particularly plaque stabilization is sparse. ApoE−/− mice with vulnerable (2-kidney, 1-clip renovascular hypertension model) or stable (1-kidney, 1-clip renovascular hypertension model) atherosclerotic plaques were used. Mice were treated with aliskiren (renin inhibitor), irbesartan (angiotensin-receptor blocker), atenolol (β-blocker), or amlodipine (calcium channel blocker). Atherosclerosis characteristics were assessed. Hemodynamic and hormonal parameters were measured. Aliskiren and irbesartan significantly prevented atherosclerosis progression in 2-kidney, 1-clip mice. Indeed, compared with …
Total citations
Scholar articles
J Nussberger, JF Aubert, K Bouzourene, M Pellegrin… - Hypertension, 2008