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Information systems (IS) departments face many challenges in today's rapidly changing environment. One approach to understanding these challenges is to survey IS managers to elicit what they consider are key issues. Studies of key IS management issues have been conducted for some years in many nations and regions. Based on such studies and a theoretical framework, this paper predicts the following key issues into the 21st century: (1) improving links between information systems strategy and business strategy, (2) developing and implementing an information architecture, (3) implementing knowledge management systems, and (4) reducing IT projects’ completion time and budget deviations. For future studies of key issues in IS management around the world, this paper provides an overview of research approaches to initial key issues selection and key issues surveys.