Authors
Elaine K Green, Rachel Raybould, Stuart Macgregor, Katherine Gordon-Smith, Jess Heron, Sally Hyde, Detelina Grozeva, Marian Hamshere, Nigel Williams, Michael J Owen, Michael C O’Donovan, Lisa Jones, Ian Jones, George Kirov, Nick Craddock
Publication date
2005/6/1
Journal
Archives of general psychiatry
Volume
62
Issue
6
Pages
642-648
Publisher
American Medical Association
Description
Context
Family and twin data suggest that, in addition to susceptibility genes specific for bipolar disorder or schizophrenia, genes exist that contribute to susceptibility across the traditional kraepelinian divide. Several studies have provided evidence that variation at the neuregulin 1 (NRG1) gene on chromosome 8p12 influences susceptibility to schizophrenia. The most consistent finding has been that one particular haplotype (the “core” haplotype) is overrepresented in cases compared with control subjects.
Objective
To investigate the possible role ofNRG1in bipolar disorder.
Design
Genetic case-control association analysis.
Setting
Subjects were unrelated and ascertained from general psychiatric inpatient and outpatient services.
Participants
Five hundred twenty-nine patients withDSM-IVbipolar I disorder and 1011 controls from the United Kingdom (100% white).
Methods
We genotyped the markers constituting the …
Total citations
Scholar articles
EK Green, R Raybould, S Macgregor, K Gordon-Smith… - Archives of general psychiatry, 2005