Authors
Sergio Salgüero, David Rojo, Juan Berenguer, Juan González‐García, Amanda Fernández‐Rodríguez, Oscar Brochado‐Kith, Cristina Díez, Victor Hontañon, Ana Virseda‐Berdices, Javier Martínez, Luis Ibañez‐Samaniego, Elba Llop‐Herrera, Coral Barbas, Salvador Resino, María A Jiménez‐Sousa, Escorial Study Group, Luis Ibáñez‐Samaniego, Leire Pérez‐Latorre, Diego Rincón, Teresa Aldámiz‐Echevarría, Vega Catalina, Pilar Miralles, Francisco Tejerina, María C Gómez‐Rico, Esther Alonso, José M Bellón, Rafael Bañares, José Arribas, José I Bernardino, Carmen Busca, Javier García‐Samaniego, Víctor Hontañón, Luz Martín‐Carbonero, Rafael Micán, María L Montes‐Ramírez, Victoria Moreno, Antonio Olveira, Ignacio Pérez‐Valero, Eulalia valencia, Juan González‐García, Elba Llop, José Luis Calleja, Agustín Albillos, Marta de Miguel, María Yllescas, Herminia Esteban
Publication date
2020/9
Journal
Liver International
Volume
40
Issue
9
Pages
2215-2227
Description
Background & Aims
Hepatitis C virus (HCV), human immunodeficiency virus (HIV) and cirrhosis induce metabolic disorders. Here, we aimed to evaluate the association of plasma metabolites with Child‐Turcotte‐Pugh (CTP) score and hepatic decompensation in HIV/HCV‐coinfected and HCV‐monoinfected patients with advanced cirrhosis.
Methods
A cross‐sectional study was carried out in 62 HIV/HCV‐coinfected and 28 HCV‐monoinfected patients. Metabolomics analysis was performed by gas chromatography‐mass spectrometry (GC‐MS) and liquid chromatography‐mass spectrometry (LC‐MS). The statistical association analysis was performed by partial least squares discriminant analysis (PLS‐DA) and generalized linear model (GLM) with binomial distribution (to analyse HIV coinfection, high alcohol intake, treatment with statins, previous HCV therapy failure and decompensation) and ordinal logistic …
Total citations
Scholar articles
S Salgüero, D Rojo, J Berenguer, J González‐García… - Liver International, 2020