Authors
Yerbol Z Kurmangaliyev, Alexander V Favorov, Noha M Osman, Kjong-Van Lehmann, Daniel Campo, Matthew P Salomon, John Tower, Mikhail S Gelfand, Sergey V Nuzhdin
Publication date
2015/12
Journal
BMC genomics
Volume
16
Pages
1-11
Publisher
BioMed Central
Description
Background
Variation within splicing regulatory sequences often leads to differences in gene models among individuals within a species. Two alleles of the same gene may express transcripts with different exon/intron structures and consequently produce functionally different proteins. Matching genomic and transcriptomic data allows us to identify putative regulatory variants associated with changes in splicing patterns.
Results
Here we analyzed natural variation of splicing patterns in the transcriptomes of 81 natural strains of Drosophila melanogaster with known genotypes. We identified dozens of genotype-specific splicing patterns associated with putative cis-splicing quantitative trait loci (sQTL). The majority of changes can be explained by mutations in splice sites. Allelic-imbalance in splicing patterns confirmed that the majority are regulated mainly by …
Total citations
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