Authors
Jacques Lacroix, Paul C Hébert, Dean A Fergusson, Alan Tinmouth, Deborah J Cook, John C Marshall, Lucy Clayton, Lauralyn McIntyre, Jeannie Callum, Alexis F Turgeon, Morris A Blajchman, Timothy S Walsh, Simon J Stanworth, Helen Campbell, Gilles Capellier, Pierre Tiberghien, Laurent Bardiaux, Leo van de Watering, Nardo J Van Der Meer, Elham Sabri, Dong Vo
Publication date
2015/4/9
Journal
New England Journal of Medicine
Volume
372
Issue
15
Pages
1410-1418
Publisher
Massachusetts Medical Society
Description
Background
Fresh red cells may improve outcomes in critically ill patients by enhancing oxygen delivery while minimizing the risks of toxic effects from cellular changes and the accumulation of bioactive materials in blood components during prolonged storage.
Methods
In this multicenter, randomized, blinded trial, we assigned critically ill adults to receive either red cells that had been stored for less than 8 days or standard-issue red cells (the oldest compatible units available in the blood bank). The primary outcome measure was 90-day mortality.
Results
Between March 2009 and May 2014, at 64 centers in Canada and Europe, 1211 patients were assigned to receive fresh red cells (fresh-blood group) and 1219 patients were assigned to receive standard-issue red cells (standard-blood group). Red cells were stored a mean (±SD) of 6.1±4.9 days in the fresh-blood group as compared with 22.0±8.4 days in the …
Scholar articles
J Lacroix, PC Hébert, DA Fergusson, A Tinmouth… - New England Journal of Medicine, 2015