Authors
Susan E Rowell, Eric N Meier, Barbara McKnight, Delores Kannas, Susanne May, Kellie Sheehan, Eileen M Bulger, Ahamed H Idris, Jim Christenson, Laurie J Morrison, Ralph J Frascone, Patrick L Bosarge, M Riccardo Colella, Jay Johannigman, Bryan A Cotton, Jeannie Callum, Jason McMullan, David J Dries, Brian Tibbs, Neal J Richmond, Myron L Weisfeldt, John M Tallon, John S Garrett, Martin D Zielinski, Tom P Aufderheide, Rajesh R Gandhi, Rob Schlamp, Bryce RH Robinson, Jonathan Jui, Lauren Klein, Sandro Rizoli, Mark Gamber, Michael Fleming, Jun Hwang, Laura E Vincent, Carolyn Williams, Audrey Hendrickson, Robert Simonson, Patricia Klotz, George Sopko, William Witham, Michael Ferrara, Martin A Schreiber
Publication date
2020/9/8
Journal
Jama
Volume
324
Issue
10
Pages
961-974
Publisher
American Medical Association
Description
Importance
Traumatic brain injury (TBI) is the leading cause of death and disability due to trauma. Early administration of tranexamic acid may benefit patients with TBI.
Objective
To determine whether tranexamic acid treatment initiated in the out-of-hospital setting within 2 hours of injury improves neurologic outcome in patients with moderate or severe TBI.
Design, Setting, and Participants
Multicenter, double-blinded, randomized clinical trial at 20 trauma centers and 39 emergency medical services agencies in the US and Canada from May 2015 to November 2017. Eligible participants (N = 1280) included out-of-hospital patients with TBI aged 15 years or older with Glasgow Coma Scale score of 12 or less and systolic blood pressure of 90 mm Hg or higher.
Interventions
Three interventions were evaluated, with treatment initiated within 2 hours of TBI: out-of-hospital tranexamic acid (1 g) bolus and in-hospital …
Scholar articles
SE Rowell, EN Meier, B McKnight, D Kannas, S May… - Jama, 2020