Authors
Saira Mirza, Usman Saeed, Jo Knight, Joel Ramirez, Donald Stuss, Julia Keith, Sean Nestor, Di Yu, Walter Swardfager, Ekaterina Rogaeva, Peter St. George Hyslop, Sandra Black, Mario Masellis
Publication date
2020/4/14
Journal
Neurology
Volume
94
Issue
15_supplement
Pages
4295
Publisher
Lippincott Williams & Wilkins
Description
Objective
To determine if APOE-ɛ4 influences the association between white matter hyperintensities (WMH) and cognitive impairment in Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB).
Background
WMH observed on structural MRI indicate cerebral small vessel disease (SVD) in most cases, are risk factors for cognitive impairment and AD, and are prevalent in dementia with DLB. However, observed cognitive performance clinically does not always reflect the severity of the WMH burden.
Design/Methods
289 patients (AD=239; DLB=50) underwent volumetric MRI, neuropsychological testing, and APOE-ɛ4 genotyping. Total WMH volumes were quantified. Neuropsychological test scores were included in a confirmatory factor analysis (CFA) to identify cognitive domains encompassing attention/executive functions, learning/ memory, and language, and factor scores for each domain were calculated …
Scholar articles
S Mirza, U Saeed, J Knight, J Ramirez, D Stuss, J Keith… - Neurology, 2020