Authors
Saira Saeed Mirza, Usman Saeed, Jo Knight, Joel Ramirez, Donald T Stuss, Julia Keith, Sean M Nestor, Di Yu, Walter Swardfager, Ekaterina Rogaeva, Peter St. George Hyslop, Sandra E Black, Mario Masellis, Alzheimer's Disease Neuroimaging Initiative
Publication date
2019/11/5
Journal
Neurology
Volume
93
Issue
19
Pages
e1807-e1819
Publisher
Lippincott Williams & Wilkins
Description
Objective
To determine if APOE ε4 influences the association between white matter hyperintensities (WMH) and cognitive impairment in Alzheimer disease (AD) and dementia with Lewy bodies (DLB).
Methods
A total of 289 patients (AD = 239; DLB = 50) underwent volumetric MRI, neuropsychological testing, and APOE ε4 genotyping. Total WMH volumes were quantified. Neuropsychological test scores were included in a confirmatory factor analysis to identify cognitive domains encompassing attention/executive functions, learning/memory, and language, and factor scores for each domain were calculated per participant. After testing interactions between WMH and APOE ε4 in the full sample, we tested associations of WMH with factor scores using linear regression models in APOE ε4 carriers (n = 167) and noncarriers (n = 122). We hypothesized that greater WMH volume would relate to worse cognition more …
Scholar articles
SS Mirza, U Saeed, J Knight, J Ramirez, DT Stuss… - Neurology, 2019