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We investigated if WMHs differentially associate with, and/or predict activities of daily living (ADLs) in patients with Alzheimer’s Disease (AD) or Dementia with Lewy Bodies (DLB).

Loss of functional independence is a common feature across all dementia diagnoses, including AD and DLB—the two most common neurodegenerative dementias. White matter hyperintensities (WMHs) on T2-weighted MRI are prevalent in both diagnoses, and also associate with disability, but this association has mostly been studied in AD. We investigated if WMHs differentially associate with, and/or predict ADLs in patients with AD or DLB

We examined if WMHs are associated with Basic and/or Instrumental ADLs (BADL and IADL) cross-sectionally in 263 patients (AD=214; DLB=49), and longitudinally in 154 patients (AD=129; DLB=25) over ~1.5 years, using multiple linear regression models. All …