Authors
Clio Der Sarkissian, Morten E Allentoft, María C Ávila-Arcos, Ross Barnett, Paula F Campos, Enrico Cappellini, Luca Ermini, Ruth Fernández, Rute Da Fonseca, Aurélien Ginolhac, Anders J Hansen, Hákon Jónsson, Thorfinn Korneliussen, Ashot Margaryan, Michael D Martin, J Víctor Moreno-Mayar, Maanasa Raghavan, Morten Rasmussen, Marcela Sandoval Velasco, Hannes Schroeder, Mikkel Schubert, Andaine Seguin-Orlando, Nathan Wales, M Thomas P Gilbert, Eske Willerslev, Ludovic Orlando
Publication date
2015/1/19
Source
Philosophical Transactions of the Royal Society B: Biological Sciences
Volume
370
Issue
1660
Pages
20130387
Publisher
The Royal Society
Description
The past decade has witnessed a revolution in ancient DNA (aDNA) research. Although the field's focus was previously limited to mitochondrial DNA and a few nuclear markers, whole genome sequences from the deep past can now be retrieved. This breakthrough is tightly connected to the massive sequence throughput of next generation sequencing platforms and the ability to target short and degraded DNA molecules. Many ancient specimens previously unsuitable for DNA analyses because of extensive degradation can now successfully be used as source materials. Additionally, the analytical power obtained by increasing the number of sequence reads to billions effectively means that contamination issues that have haunted aDNA research for decades, particularly in human studies, can now be efficiently and confidently quantified. At present, whole genomes have been sequenced from ancient anatomically …
Total citations
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Scholar articles
C Der Sarkissian, ME Allentoft, MC Ávila-Arcos… - Philosophical Transactions of the Royal Society B …, 2015