Authors
Alexander S Hatoum, Sarah MC Colbert, Emma C Johnson, Spencer B Huggett, Joseph D Deak, Gita A Pathak, Mariela V Jennings, Sarah E Paul, Nicole R Karcher, Isabella Hansen, David AA Baranger, Alexis Edwards, Andrew D Grotzinger, Elliot M Tucker-Drob, Henry R Kranzler, Lea K Davis, Sandra Sanchez-Roige, Renato Polimanti, Joel Gelernter, Howard J Edenberg, Ryan Bogdan, Arpana Agrawal
Publication date
2023/3
Journal
Nature Mental Health
Volume
1
Issue
3
Pages
210-223
Publisher
Nature Publishing Group US
Description
Genetic liability to substance use disorders can be parsed into loci that confer general or substance-specific addiction risk. We report a multivariate genome-wide association meta-analysis that disaggregates general and substance-specific loci from published summary statistics of problematic alcohol use, problematic tobacco use, cannabis use disorder and opioid use disorder in a sample of 1,025,550 individuals of European descent and 92,630 individuals of African descent. Nineteen independent single-nucleotide polymorphisms were genome-wide significant (P < 5 × 10–8) for the general addiction risk factor (addiction-rf), which showed high polygenicity. Across ancestries, PDE4B was significant (among other genes), suggesting dopamine regulation as a cross-substance vulnerability. An addiction-rf polygenic risk score was associated with substance use disorders, psychopathologies, somatic conditions …
Total citations
Scholar articles
AS Hatoum, SMC Colbert, EC Johnson, SB Huggett… - Nature Mental Health, 2023