Authors
CL Gregson, SA Steel, KP O’Rourke, K Allan, J Ayuk, Ashok Bhalla, Gavin Clunie, N Crabtree, Ignac Fogelman, A Goodby, CM Langman, S Linton, E Marriott, E McCloskey, KE Moss, T Palferman, S Panthakalam, KES Poole, MD Stone, J Turton, D Wallis, S Warburton, J Wass, EL Duncan, MA Brown, G Davey-Smith, Jonathan H Tobias
Publication date
2012/2
Journal
Osteoporosis International
Volume
23
Pages
643-654
Publisher
Springer-Verlag
Description
Summary
High bone mineral density on routine dual energy X-ray absorptiometry (DXA) may indicate an underlying skeletal dysplasia. Two hundred fifty-eight individuals with unexplained high bone mass (HBM), 236 relatives (41% with HBM) and 58 spouses were studied. Cases could not float, had mandible enlargement, extra bone, broad frames, larger shoe sizes and increased body mass index (BMI). HBM cases may harbour an underlying genetic disorder.
Introduction
High bone mineral density is a sporadic incidental finding on routine DXA scanning of apparently asymptomatic individuals. Such individuals may have an underlying skeletal dysplasia, as seen in LRP5 mutations. We aimed to characterize unexplained HBM and determine the potential for an underlying skeletal dysplasia.
Methods
Two hundred fifty …
Scholar articles
CL Gregson, SA Steel, KP O'Rourke, K Allan, J Ayuk… - Osteoporosis International, 2012