Authors
George R Washko, Gary M Hunninghake, Isis E Fernandez, Mizuki Nishino, Yuka Okajima, Tsuneo Yamashiro, James C Ross, Raúl San José Estépar, David A Lynch, John M Brehm, Katherine P Andriole, Alejandro A Diaz, Ramin Khorasani, Katherine D'Aco, Frank C Sciurba, Edwin K Silverman, Hiroto Hatabu, Ivan O Rosas
Publication date
2011/3/10
Journal
New England Journal of Medicine
Volume
364
Issue
10
Pages
897-906
Publisher
Massachusetts Medical Society
Description
Background
Cigarette smoking is associated with emphysema and radiographic interstitial lung abnormalities. The degree to which interstitial lung abnormalities are associated with reduced total lung capacity and the extent of emphysema is not known.
Methods
We looked for interstitial lung abnormalities in 2416 (96%) of 2508 high-resolution computed tomographic (HRCT) scans of the lung obtained from a cohort of smokers. We used linear and logistic regression to evaluate the associations between interstitial lung abnormalities and HRCT measurements of total lung capacity and emphysema.
Results
Interstitial lung abnormalities were present in 194 (8%) of the 2416 HRCT scans evaluated. In statistical models adjusting for relevant covariates, interstitial lung abnormalities were associated with reduced total lung capacity (-0.444 liters; 95% confidence interval [CI], -0.596 to -0.292; P<0.001) and a lower …
Total citations
Scholar articles
GR Washko, GM Hunninghake, IE Fernandez… - New England Journal of Medicine, 2011