Authors
Gary M Hunninghake, Hiroto Hatabu, Yuka Okajima, Wei Gao, Josée Dupuis, Jeanne C Latourelle, Mizuki Nishino, Tetsuro Araki, Oscar E Zazueta, Sila Kurugol, James C Ross, Raúl San José Estépar, Elissa Murphy, Mark P Steele, James E Loyd, Marvin I Schwarz, Tasha E Fingerlin, Ivan O Rosas, George R Washko, George T O'Connor, David A Schwartz
Publication date
2013/6/6
Journal
New England Journal of Medicine
Volume
368
Issue
23
Pages
2192-2200
Publisher
Massachusetts Medical Society
Description
Background
A common promoter polymorphism (rs35705950) in MUC5B, the gene encoding mucin 5B, is associated with idiopathic pulmonary fibrosis. It is not known whether this polymorphism is associated with interstitial lung disease in the general population.
Methods
We performed a blinded assessment of interstitial lung abnormalities detected in 2633 participants in the Framingham Heart Study by means of volumetric chest computed tomography (CT). We evaluated the relationship between the abnormalities and the genotype at the rs35705950 locus.
Results
Of the 2633 chest CT scans that were evaluated, interstitial lung abnormalities were present in 177 (7%). Participants with such abnormalities were more likely to have shortness of breath and chronic cough and reduced measures of total lung and diffusion capacity, as compared with participants without such abnormalities. After adjustment for …
Scholar articles
GM Hunninghake, H Hatabu, Y Okajima, W Gao… - New England Journal of Medicine, 2013