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Quantitative magnetization transfer imaging (qMTI) increases specificity to macromolecular content in tissue by modeling the exchange process between the liquid and the macromolecular pool. However, its use has been mostly restricted to researchers that have developed these methods, in part due to the need to write complicated in‐house software for modeling and data analysis. We have developed a software package (qMTLab) with a simple and easy to use graphical user interface that unifies three of the most widely used qMTI methods: MT spoiled gradient echo (MT‐SPGR), MT balanced steady‐state free precession (MT‐bSSFP), and selective inversion recovery with fast spin echo (SIR‐FSE). qMTLab is free open‐source software that allows anyone interested in using these methods to easily simulate qMTI data, compare the performance of the methods under various experimental conditions, define new …