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An important challenge for conserving and managing marine ecosystems is to advance our understanding of how multiple human stressors, environmental factors and marine resources interact and influence each other. The ecosystems of the Israeli Mediterranean coast have undergone significant ecological changes in recent decades, caused primarily by the introduction of alien species, fishing and the warming of the waters. Here we used a food-web model representing the continental shelf of the Israeli Mediterranean coast to explore the historical dynamics of the area considering the combined effect of alien species, fishing activities and changes in sea surface temperature and primary productivity. The food-web model was fitted to available time series of data from the early 1990s to 2010 using the temporal dynamic module of the Ecopath with Ecosim modeling approach. An important challenge was to model …