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DOI: 10.1002/adma. 201402797 various analytes and in situ imaging/monitoring pathological lesions.[8] For example, Weissleder et al.[4a, 9] exploited crystal violet, antibody, and DNA modified magnetic nanoparticles (MNPs) for MR detection of bacteria. In comparison with MNP-based T2-type MR agents which produce a negative image contrast, however, bacterial sensing based on positive contrastgenerating T1-type agents has been far less explored. In addition, we envisage that the construction of multimodal wholebacterium sensing platform by integrating two or more detection modes (eg, optical and MR imaging) would endow extra advantages such as complementing the limitation associated with each modality, cross-validation, and maximizing the synergistic effect.[10]

As for antibacterial agents, various types of small molecule antibiotics have been developed and daily used in the battle against …