View article

Background

Schizophrenia is characterized by persistent cognitive deficits. Transcranial direct current stimulation (tDCS) is a safe and noninvasive brain stimulation method, and several studies showed that it can improve cognitive function in schizophrenic. The current study was a double-blind sham-controlled study to investigate neural alternations before and after tDCS under different task demands.

Methods

26 schizophrenic inpatients, participated in double-blind study of 10 sessions of active or sham tDCS (active tDCS for 20 min, 2 mA), with anode placed over the left DLPFC and the cathode over contralateral supraorbital ridge. Before and after 10 sessions of tDCS, fMRI were scanned under 0-back and 2-back tasks and resting state (RS). The activation mapping during 0 back and 2 back working memory tasks was analyzed to check the difference between low and high level tasks, and RS connectivity will be …