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A new comprehensive water, energy, food, greenhouse gas (WEFG) nexus index was developed to capture the interrelationships between them. A total of 11 indicators were applied to consider the interplay of resources consumption, productivity, economic issues, and carbon emission as one of the most critical issues regarding sustainable agricultural development. The proposed WEFG index was evaluated for crop pattern optimization. The results showed that the WEFG ranged from 0.162 to 0.658, which were calculated respectively for almonds and rice due to their energy consumption and carbon emission levels. The optimal cultivation pattern based on WEFG leads to 11% and 15.8% reductions in water and energy consumption, even with a 2.3% increase in cultivation area. The estimated profit for optimal pattern based on WEFG decreased by 13.67% due to lower cultivation levels of high‐yield crops such as …