Authors
Sonam Dilwali, Lukas D Landegger, Vitor YR Soares, Daniel G Deschler, Konstantina M Stankovic
Publication date
2015/12/22
Journal
Scientific reports
Volume
5
Issue
1
Pages
18599
Publisher
Nature Publishing Group UK
Description
Vestibular schwannomas (VSs) are the most common tumours of the cerebellopontine angle. Ninety-five percent of people with VS present with sensorineural hearing loss (SNHL); the mechanism of this SNHL is currently unknown. To establish the first model to study the role of VS-secreted factors in causing SNHL, murine cochlear explant cultures were treated with human tumour secretions from thirteen different unilateral, sporadic VSs of subjects demonstrating varied degrees of ipsilateral SNHL. The extent of cochlear explant damage due to secretion application roughly correlated with the subjects’ degree of SNHL. Secretions from tumours associated with most substantial SNHL resulted in most significant hair cell loss and neuronal fibre disorganization. Secretions from VSs associated with good hearing or from healthy human nerves led to either no effect or solely fibre disorganization. Our results are the first to …
Scholar articles
S Dilwali, LD Landegger, VYR Soares, DG Deschler… - Scientific reports, 2015