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Objective: To identify genes whose expression is most characteristic of chronic rhinosinusitis and aspirin‐sensitive asthma through genome‐wide transcriptional profiling of nasal polyp tissue.

Study Design: Prospective, controlled study conducted at a tertiary care institution.

Methods: Thirty genome‐wide expression microarrays were used to compare nasal polyp tissue from patients with chronic rhinosinusitis alone (CRS, n = 10) or chronic rhinosinusitis and a history of aspirin‐sensitive asthma (ASA, n = 10) to normal sinonasal mucosa from patients who underwent surgery for non‐sinus related conditions (controls, n = 10). Genes found to be most characteristic of each polyp phenotype, as determined from bioinformatic analyses, were validated using real‐time quantitative polymerase chain reaction (RT‐PCR) and immunohistochemistry in different patient sets.

Results: The transcriptional signature of the control …