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Commonly studied equatomic single-phase FCC high entropy alloys based on 3d transition metals like NiCoFeCr do not provide adequate strength and radiation resistance at high doses for nuclear structural applications. In the current study, the major alloying effects like lattice distortion, ordering and clustering tendencies were investigated by adding low concentration of Pd, Al, or Cu respectively to study the doping effects on the ion irradiation response of NiCoFeCr alloy. The alloys were irradiated with 3 MeV Ni²⁺ ions at 500°C to a fluence of 1 × 10¹⁷/cm² at a beam flux of approximately 2.8 × 10¹² ions/cm²/s. The microstructural evolution upon irradiation i.e., formation of dislocation networks, radiation induced segregation and precipitation, and void formation were studied in detail. Post-irradiation characterization results showed that a Pd addition leads to a high void nucleation rate but controlled void …