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Patients with chronic or advancing disease often generate perceptions that they or others can control aspects of their illness such as its symptoms, course, and treatment. This article considers self‐generated feelings of control, and provides evidence from patients with cardiac disease, cancer, and AIDS concerning the adaptiveness of these feelings. The research suggests that beliefs in personal control generally appear to be adaptive. Perceptions of control do not appear to be explained by the absence of negative affectivity, and instead, appear to reduce anxiety and depression. Cognitions concerning control by others yield more mixed results. Whereas women and patients with good prognoses appear to profit psychologically from feelings of vicarious control, men and patients with poor prognoses do not. Implications for the literatures on psychological control, the illusion of control, and adjustment to chronic …