Authors
Michael EJ Lean, Wilma S Leslie, Alison C Barnes, Naomi Brosnahan, George Thom, Louise McCombie, Tara Kelly, Keaton Irvine, Carl Peters, Sviatlana Zhyzhneuskaya, Kieren G Hollingsworth, Ashley J Adamson, Falko F Sniehotta, John C Mathers, Yvonne McIlvenna, Paul Welsh, Alex McConnachie, Alasdair McIntosh, Naveed Sattar, Roy Taylor
Publication date
2024/4/1
Journal
The Lancet Diabetes & Endocrinology
Volume
12
Issue
4
Pages
233-246
Publisher
Elsevier
Description
Background
In DiRECT, a randomised controlled effectiveness trial, weight management intervention after 2 years resulted in mean weight loss of 7·6 kg, with 36% of participants in remission of type 2 diabetes. Of 36 in the intervention group who maintained over 10 kg weight loss at 2 years, 29 (81%) were in remission. Continued low-intensity dietary support was then offered up to 5 years from baseline to intervention participants, aiming to maintain weight loss and gain clinical benefits. This extension study was designed to provide observed outcomes at 5 years.
Methods
The DiRECT trial took place in primary care practices in the UK. Participants were individuals aged 20–65 years who had less than 6 years' duration of type 2 diabetes, a BMI greater than 27 kg/m2, and were not on insulin. The intervention consisted of withdrawal of antidiabetic and antihypertensive drugs, total diet replacement (825–853 kcal per …
Total citations
20249
Scholar articles
MEJ Lean, WS Leslie, AC Barnes, N Brosnahan… - The Lancet Diabetes & Endocrinology, 2024