Authors
Frederick CW Wu, Abdelouahid Tajar, Jennifer M Beynon, Stephen R Pye, Alan J Silman, Joseph D Finn, Terence W O'Neill, Gyorgy Bartfai, Felipe F Casanueva, Gianni Forti, Aleksander Giwercman, Thang S Han, Krzysztof Kula, Michael EJ Lean, Neil Pendleton, Margus Punab, Steven Boonen, Dirk Vanderschueren, Fernand Labrie, Ilpo T Huhtaniemi
Publication date
2010/7/8
Journal
New England Journal of Medicine
Volume
363
Issue
2
Pages
123-135
Publisher
Massachusetts Medical Society
Description
Background
The association between aging-related testosterone deficiency and late-onset hypogonadism in men remains a controversial concept. We sought evidence-based criteria for identifying late-onset hypogonadism in the general population on the basis of an association between symptoms and a low testosterone level.
Methods
We surveyed a random population sample of 3369 men between the ages of 40 and 79 years at eight European centers. Using questionnaires, we collected data with regard to the subjects' general, sexual, physical, and psychological health. Levels of total testosterone were measured in morning blood samples by mass spectrometry, and free testosterone levels were calculated with the use of Vermeulen's formula. Data were randomly split into separate training and validation sets for confirmatory analyses.
Results
In the training set, symptoms of poor morning erection, low …
Total citations
Scholar articles
FCW Wu, A Tajar, JM Beynon, SR Pye, AJ Silman… - New England Journal of Medicine, 2010