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The extent of prehistoric human impact on the environment is a contentious topic in various palaeo-environmental sciences. The long history of humans in Australia and its extensive fire-prone biota makes this continent a key research area for better characterization of prehistoric human–fire interactions. Here we use statistically robust cross-correlation of archaeological radiocarbon data (n = 4102 ages from 1616 sites) and a new synthesis of charcoal records (n = 155 sites) to test for any relationship between people and fire over the last 20,000 years at continental and regional (25–45°S) scales. We find that the statistical correlation between the two datasets is weak at both spatial scales, with short-lived synchronous responses only in the terminal Pleistocene–Holocene transition, at the onset of the mid-Holocene climatic optimum (~ 10–7 ka) and during significant transitions of El Niño Southern Oscillation (~ 5–4 …