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Of course. What technology can't be? And that is particularly true of technologies that strike as close to our humanity as those that involve reproduction. Human germline genome editing could certainly be used in ways that cause needless harm or more harm than good. Important questions are whether those results can—and likely will—be averted? This chapter surveys a few of the very real issues that are most discussed as problems for this technology (and many others): safety, coercion, equity, diversity, and enhancement. But first I want to dispose of a common, but illogical, objection to all of human germline genome editing: "unnaturalness."¹