Authors
Darrell J Triulzi, Steven Kleinman, Ram M Kakaiya, Michael P Busch, Philip J Norris, Whitney R Steele, Simone A Glynn, Christopher D Hillyer, Patricia Carey, Jerome L Gottschall, Edward L Murphy, Jorge A Rios, Paul M Ness, David J Wright, Danielle Carrick, George B Schreiber
Publication date
2009/9
Journal
Transfusion
Volume
49
Issue
9
Pages
1825-1835
Publisher
Blackwell Publishing Inc
Description
BACKGROUND: Antibodies to human leukocyte antigens (HLA) in donated blood have been implicated as a cause of transfusion‐related acute lung injury (TRALI). A potential measure to reduce the risk of TRALI includes screening plateletpheresis donors for HLA antibodies. The prevalence of HLA antibodies and their relationship to previous transfusion or pregnancy in blood donors was determined.
STUDY DESIGN AND METHODS: A total of 8171 volunteer blood donors were prospectively recruited by six US blood centers from December 2006 to May 2007. Donors provided a detailed history of pregnancy and transfusion and a sample for HLA Class I and II antibody testing by multiantigen bead flow analysis.
RESULTS: A total of 8171 donors were enrolled; 7920 (96.9%) had valid HLA antibody test results and 7841 (99%) of those had complete pregnancy and transfusion information. The prevalence of any …
Total citations
Scholar articles
DJ Triulzi, S Kleinman, RM Kakaiya, MP Busch… - Transfusion, 2009