Authors
Michael J Boivin, Miriam Chernoff, Lee Fairlie, Barbara Laughton, Bonnie Zimmer, Celeste Joyce, Linda Barlow-Mosha, Mutsawashe Bwakura-Dangarembizi, Tichaona Vhembo, Mmule Ratswana, Portia Kamthunzi, Katie McCarthy, Itziar Familiar-Lopez, Patrick Jean-Philippe, Joan Coetzee, Nasreen Abrahams, Hermien Gous, Avy Violari, Mark F Cotton, Paul E Palumbo
Publication date
2020/10/1
Journal
Clinical Infectious Diseases
Volume
71
Issue
7
Pages
e105-e114
Publisher
Oxford University Press
Description
Background
Children living with human immunodeficiency virus (HIV) are at neuropsychological risk for cognitive and motor dysfunction. However, few prospective, multi-site studies have evaluated neuropsychological outcomes longitudinally among perinatally infected African children who received early antiretroviral treatment (ART).
Methods
We enrolled 611 children aged 5 to 11 years at 6 sites (South Africa [3], Zimbabwe, Malawi, Uganda). Of these, there were 246 children living with HIV (HIV+) who were initiated on ART before 3 years of age in a prior clinical trial comparing nevirapine to lopinavir/ritonavir (International Maternal Pediatric Adolescent Acquired Immunodeficiency Syndrome Clinical Trials [IMPAACT] P1060); 183 age-matched, exposed but uninfected (HEU) children; and 182 unexposed and uninfected (HUU) children. They were compared across 3 …
Scholar articles
MJ Boivin, M Chernoff, L Fairlie, B Laughton, B Zimmer… - Clinical Infectious Diseases, 2020