Authors
Luca Cocchi, Ivanei E Bramati, Andrew Zalesky, Emi Furukawa, Leonardo F Fontenelle, Jorge Moll, Gail Tripp, Paulo Mattos
Publication date
2012/12/5
Journal
Journal of Neuroscience
Volume
32
Issue
49
Pages
17753-17761
Publisher
Society for Neuroscience
Description
Attention-deficit/hyperactivity disorder (ADHD) is characterized by symptoms of inattention and hyperactivity/impulsivity that often persist in adulthood. There is a growing consensus that ADHD is associated with abnormal function of diffuse brain networks, but such alterations remain poorly characterized. Using resting-state functional magnetic resonance imaging, we characterized multivariate (complex network measures), bivariate (network-based statistic), and univariate (regional homogeneity) properties of brain networks in a non-clinical, drug-naive sample of high-functioning young men and women with ADHD (nine males, seven females) and a group of matched healthy controls. Data from our sample allowed the isolation of intrinsic functional connectivity alterations specific to ADHD diagnosis and symptoms that are not related to developmental delays, general cognitive dysfunction, or history of medication …
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