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Background and objective:  The aim of this study was to investigate oxidative stress status in different stages and histological types of lung cancer.

Methods:  Forty‐nine lung cancer patients, who had not received any therapy, and 20 healthy subjects were chosen for the study. Lung cancer patients were divided into those with early stage or advanced stage disease. The tumour type was adenocarcinoma in 24 patients, squamous cell carcinoma in 21 and large cell carcinoma in four. We measured serum nitrite, nitrate, ascorbic acid, retinol, β‐carotene and ceruloplasmin levels, and whole‐blood malondialdehyde, reduced glutathione levels and catalase activity in patients with non‐small cell lung carcinoma and healthy subjects.

Results:  Statistically significant differences between the patient group and the control group were detected for all biochemical parameters. Mean malondialdehyde, nitrite, nitrate and …