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AT1AA have been shown to contribute to the pathogenesis and clinical syndrome of preeclampsia. The pathogenesis of preeclampsia is primarily attributed to poor placentation and subsequent placental hypoxia. A reduced uterine perfusion pressure rat model of preeclampsia has shown that placental ischaemia is a stimulus for AT1AA mediated hypertension.

Assess the effect of placental ischaemia on the concentration of AT1AA in a non-human primate animal model (Papio Hamadryas) of experimental preeclampsia.

Experimental preeclampsia was achieved by surgically induced uteroplaental ischaemia (UPI). Plasma and urine samples were taken pre (day 0) and post UPI (7 days, 14 days, 21 days, 28 days, 35 days). Proteinuria was measured by urine protein to creatinine ratio, blood pressure was measured by intra-arterial radio-telemetry and plasma soluble fms like tyrosine …