Authors
Suzanne Pears, Neroli Sunderland, Alicia Dennis, Shirlene Lim, Katrina Chau, Shikha Aggarwal, Scott Heffernan, Ryan Downey, Robert Ogle, John Thompson, Jim Iliopoulos, Annemarie Hennessy, Angela Makris
Publication date
2016/7/1
Journal
Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health
Volume
6
Issue
3
Pages
211
Publisher
Elsevier
Description
Introduction
Increased blood pressure (BP), especially sudden, unexpected and severe rises in women with preeclampsia considerably increases the risk of peripartum complications. These risks are even more acute in the context of general anaesthesia.
Objectives
To assess the effects of antihypertensive drugs on short and long term blood pressure variability when used concurrently with propofol and ketamine anaesthesia.
Methods
Blood Pressure was measured during anaesthesia in six, pregnant Papio hamadryas (baboons) with experimental preeclampsia (EPE). Animals were given antihypertensives commonly used to manage preeclampsia (labetalol, methyldopa and hydralazine) at equipotent doses equivalent to mild starting dose rates commonly used in women with preeclampsia.
Results
When anaesthetised with ketamine (most commonly used anaesthetic agent in EPE), systolic BP increased significantly …
Scholar articles
S Pears, N Sunderland, A Dennis, S Lim, K Chau… - Pregnancy Hypertension: An International Journal of …, 2016