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In this editorial, we discuss approaches to the empirical test of gain and loss cycles as described within Hobfoll's conservation of resources theory (COR). We present COR theory's basic assumptions about gain and loss cycles and critically discuss typical empirical studies that aim at testing these assumptions. We highlight conceptual and empirical problems when testing gain and loss cycles of resources and provide guidance for researchers with respect to theoretical, temporal, and data-analytic aspects. We offer some suggestions for constructive replications and reproducibility.