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Sensory-specific satiety, which is defined as a relative decrease in pleasantness, is increased by greater oro-sensory stimulation. Both sensory-specific satiety and pleasantness affect taste activation in the orbitofrontal cortex. In contrast, metabolic satiety, which results from energy intake, is expected to modulate taste activation in reward areas. The aim of this study was to determine the effects of the amount of oro-sensory stimulation and energy content on consumption-induced changes in taste activation. Ten men participated in a 2×2 randomized crossover study. Subjects were scanned twice using functional magnetic resonance imaging: after fasting for at least 2h and after treatment, on four occasions. Treatment consisted of the ingestion of 450mL of orangeade (sweetened with 10% sucrose or non-caloric sweeteners) at 150mL/min, with either small (5mL) or large (20mL) sips. During scanning, subjects …