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A 15 L high-solid mesophilic AnMBR was operated for the digestion of food waste, primary sludge and excess sludge. The digestion performance was evaluated from the perspective of methane generation, permeate quality and organic reduction. Furthermore, the change in the microbial community was investigated by 16S rRNA gene analysis. The results showed that the introduction of sludge decreased the H₂S levels in biogas compared with the mono-digestion of food waste and the co-digestion with food waste increased biogas and methane production compared with the mono-digestion of sludge. A substitution ratio of 25 % became a turning point of permeate composition and reaction rates. The energy recovery ratios of the mesophilic AnMBR were over 75 % based on stoichiometric analysis. In reaction kinetics analysis, hydrolysis as the first step of anaerobic digestion was found to be most influenced by …