Authors
Lance B Price, Marc Stegger, Henrik Hasman, Maliha Aziz, Jesper Larsen, Paal Skytt Andersen, Talima Pearson, Andrew E Waters, Jeffrey T Foster, James Schupp, John Gillece, Elizabeth Driebe, Cindy M Liu, Burkhard Springer, Irena Zdovc, Antonio Battisti, Alessia Franco, Jacek Żmudzki, Stefan Schwarz, Patrick Butaye, Eric Jouy, Constanca Pomba, M Concepción Porrero, Raymond Ruimy, Tara C Smith, D Ashley Robinson, J Scott Weese, Carmen Sofia Arriola, Fangyou Yu, Frederic Laurent, Paul Keim, Robert Skov, Frank M Aarestrup
Publication date
2012/3/1
Journal
MBio
Volume
3
Issue
1
Pages
10.1128/mbio. 00305-11
Publisher
American Society for Microbiology
Description
Since its discovery in the early 2000s, methicillin-resistant Staphylococcus aureus (MRSA) clonal complex 398 (CC398) has become a rapidly emerging cause of human infections, most often associated with livestock exposure. We applied whole-genome sequence typing to characterize a diverse collection of CC398 isolates (n = 89), including MRSA and methicillin-susceptible S. aureus (MSSA) from animals and humans spanning 19 countries and four continents. We identified 4,238 single nucleotide polymorphisms (SNPs) among the 89 core genomes. Minimal homoplasy (consistency index = 0.9591) was detected among parsimony-informative SNPs, allowing for the generation of a highly accurate phylogenetic reconstruction of the CC398 clonal lineage. Phylogenetic analyses revealed that MSSA from humans formed the most ancestral clades. The most derived lineages were composed predominantly of …
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Scholar articles
LB Price, M Stegger, H Hasman, M Aziz, J Larsen… - MBio, 2012