Authors
Massimo Pifferi, Andrew Bush, Giovanni Pioggia, Davide Caramella, Gennaro Tartarisco, Maria Di Cicco, Marta Zangani, Iolanda Chinellato, Fabrizio Maggi, Giovanna Tezza, Pierantonio Macchia, Attilio Boner
Publication date
2012/11/1
Journal
Thorax
Volume
67
Issue
11
Pages
993-999
Publisher
BMJ Publishing Group Ltd
Description
Background
In primary ciliary dyskinesia (PCD) lung damage is usually evaluated by high-resolution CT (HRCT).
Objective
To evaluate whether HRCT abnormalities and Pseudomonas aeruginosa infection were better predicted by spirometry or plethysmography.
Methods
A cross-sectional study performed in consecutive patients with PCD who underwent sputum culture, spirometry, plethysmography and HRCT within 48 h. Principal component analysis and soft computing were used for data evaluation.
Results
Fifty patients (26 children) were studied. P aeruginosa infection was found in 40% of the patients and bronchiectasis in 88%. There was a correlation between infection with P aeruginosa and extent of bronchiectasis (p=0.009; r =0.367) and air-trapping (p=0.03; r =0.315). Moreover, there was an association between infection with P aeruginosa and residual volume (RV) values >150% (p=0.04) and RV …
Scholar articles
M Pifferi, A Bush, G Pioggia, D Caramella, G Tartarisco… - Thorax, 2012