Authors
Sonja De Zwarte, Rachel Brouwer, Manon Hillegers, Wiepke Cahn, Hilleke Hulshoff Pol, René Kahn, Kathryn Alpert, Lei Wang, Elvira Bramon, Fergus Kane, Robin Murray, Tomas Hajek, Martin Alda, Gloria Roberts, Philip Mitchell, Peter Schofield, Janice Fullerton, Anja Richter, Oliver Gruber, Aurora Bonvino, Alessandro Bertolino, Annabella Di Giorgio, Xavier Caseras, Ali Saffet Gonul, Mehmet Cagdas Eker, Fatma Simsek, Scott Fears, Carrie Bearden, David Glahn, Theo van Erp, Paul Thompson, Ole Andreassen, Jessica Turner, Neeltje van Haren
Publication date
2017/5/15
Journal
Biological Psychiatry
Volume
81
Issue
10
Pages
S114-S115
Publisher
Elsevier
Description
Background
First-degree relatives of schizophrenia (SZ) and bipolar disorder (BD) patients show brain abnormalities. Through the ENIGMA-SZ and BD Working Groups, we compare different types of SZ or BD first-degree relatives (ie, co-twins, siblings, offspring, parents) to healthy controls (HC) on global and subcortical brain measures. In this abstract, we limit ourselves to total brain (TB) and hippocampal volume.
Methods
To date, 3,033 individuals from 16 independent studies were included. MRI scans were processed with FreeSurfer. Linear mixed model analyses were performed comparing each type of relative to HC, while taking family relatedness into account. Centered age, age squared and sex (and lithium for BD) were included as covariates. Cohen’sd effect sizes were obtained at each site and then pooled using an inverse variance-weighted random-effects meta-analysis for each relative group separately …
Scholar articles
S De Zwarte, R Brouwer, M Hillegers, W Cahn, HH Pol… - Biological Psychiatry, 2017