Authors
Jonathan Vöglein, Katrina L Paumier, Mathias Jucker, Oliver Preische, Christoph Laske, Chengjie Xiong, Peter R Schofield, Stephen Salloway, Hiroshi Mori, Nigel J Cairns, John C Morris, Randall J Bateman, Adrian Danek, Johannes Levin
Publication date
2017/7
Journal
Alzheimer's & Dementia
Volume
13
Issue
7S_Part_21
Pages
P1043-P1044
Publisher
The Alzheimer's Association, Inc.
Description
Methods
We utilized data from the Dominantly Inherited Alzheimer's Network (DIAN) observational study to assess motor dysfunction as determined by the Unified Parkinson Disease Rating Scale part-three (UPDRS-III). We analyzed UPDRS-III scores (0 (best) to 108 (worst)) at baseline for all 433 participants at data freeze 10. We compared the frequency (UPDRS-III 0 vs.> 0) and severity (UPDRS-III scores) of motor symptoms between mutation carriers (MC) and non-carriers (NC). In MC, correlations of UPDRS-III scores with estimated years to symptom onset (EYO) and Clinical Dementia Rating Scale-Sum of Boxes (CDR-SOB) were analyzed. Fisher's exact test, Mann-Whitney U test, Spearman correlation and Holm-Bonferroni correction were used.
Results
MC exhibited a higher frequency (28.4% vs. 12.8%; p= 0.0001) and severity (mean UPDRS-III scores 2.0 vs. 0.4; p= 0.00007) of motor symptoms compared to …
Scholar articles
J Vöglein, KL Paumier, M Jucker, O Preische, C Laske… - Alzheimer's & Dementia, 2017