Authors
Olivia Wagemann, Yan Li, Jason Hassenstab, Andrew J Aschenbrenner, Nicole S McKay, Brian A Gordon, Tammie LS Benzinger, Chengjie Xiong, Carlos Cruchaga, Alan E Renton, Richard J Perrin, Sarah B Berman, Jasmeer P Chhatwal, Martin R Farlow, Gregory S Day, Takeshi Ikeuchi, Mathias Jucker, Francisco Lopera, Hiroshi Mori, James M Noble, Raquel Sánchez‐Valle, Peter R Schofield, John C Morris, Alisha Daniels, Johannes Levin, Randall J Bateman, Eric McDade, Jorge J Llibre‐Guerra, Dominantly Inherited Alzheimer Network
Publication date
2024/1
Journal
Alzheimer's & Dementia
Volume
20
Issue
1
Pages
47-62
Description
INTRODUCTION
Studies suggest distinct differences in the development, presentation, progression, and response to treatment of Alzheimer's disease (AD) between females and males. We investigated sex differences in cognition, neuroimaging, and fluid biomarkers in dominantly inherited AD (DIAD).
METHODS
Three hundred twenty‐five mutation carriers (55% female) and one hundred eighty‐six non‐carriers (58% female) of the Dominantly Inherited Alzheimer Network Observational Study were analyzed. Linear mixed models and Spearman's correlation explored cross‐sectional sex differences in cognition, cerebrospinal fluid (CSF) biomarkers, Pittsburgh compound B positron emission tomography (11C‐PiB PET) and structural magnetic resonance imaging (MRI).
RESULTS
Female carriers performed better than males on delayed recall and processing speed despite similar hippocampal volumes. As the …
Total citations
20232
Scholar articles
O Wagemann, Y Li, J Hassenstab, AJ Aschenbrenner… - Alzheimer's & Dementia, 2024