Authors
Julie K Wisch, Nicole S McKay, Anna H Boerwinkle, James Kennedy, Shaney Flores, Benjamin L Handen, Bradley T Christian, Elizabeth Head, Mark Mapstone, Michael S Rafii, Sid E O’Bryant, Julie C Price, Charles M Laymon, Sharon J Krinsky-McHale, Florence Lai, H Diana Rosas, Sigan L Hartley, Shahid Zaman, Ira T Lott, Dana Tudorascu, Matthew Zammit, Adam M Brickman, Joseph H Lee, Thomas D Bird, Annie Cohen, Patricio Chrem, Alisha Daniels, Jasmeer P Chhatwal, Carlos Cruchaga, Laura Ibanez, Mathias Jucker, Celeste M Karch, Gregory S Day, Jae-Hong Lee, Johannes Levin, Jorge Llibre-Guerra, Yan Li, Francisco Lopera, Jee Hoon Roh, John M Ringman, Charlene Supnet-Bell, Christopher H van Dyck, Chengjie Xiong, Guoqiao Wang, John C Morris, Eric McDade, Randall J Bateman, Tammie LS Benzinger, Brian A Gordon, Beau M Ances, Howard J Aizenstein, Howard F Andrews, Karen Bell, Rasmus M Birn, Peter Bulova, Amrita Cheema, Kewei Chen, Isabel Clare, Lorraine Clark, Ann D Cohen, John N Constantino, Eric W Doran, Eleanor Feingold, Tatiana M Foroud, Sigan L Hartley, Christy Hom, Lawrence Honig, Milos D Ikonomovic, Sterling C Johnson, Courtney Jordan, M Ilyas Kamboh, David Keator, William E Klunk, Julia K Kofler, William C Kreisl, Sharon J Krinsky-McHale, Patrick Lao, Charles Laymon, Ira T Lott, Victoria Lupson, Chester A Mathis, Davneet S Minhas, Neelesh Nadkarni, Deborah Pang, Melissa Petersen, Julie C Price, Margaret Pulsifer, Eric Reiman, Batool Rizvi, Marwan N Sabbagh, Nicole Schupf, Dana L Tudorascu, Rameshwari Tumuluru, Benjamin Tycko, Badri Varadarajan, Desiree A White, Michael A Yassa, Fan Zhang, Randall Bateman, Alisha J Daniels, Laura Courtney, Jorge J Llibre-Guerra, Chengie Xiong, Xiong Xu, Ruijin Lu, Emily Gremminger, Richard J Perrin, Erin Franklin, Gina Jerome, Elizabeth Herries, Jennifer Stauber, Bryce Baker, Matthew Minton, Alison M Goate, Alan E Renton, Danielle M Picarello, Tammie Benzinger, Brian A Gordon, Russall Hornbeck, Jason Hassenstab, Jennifer Smith, Sarah Stout, Andrew J Aschenbrenner, Celeste M Karch, Jacob Marsh, John C Morris, David M Holtzman, Nicolas Barthelemy, Jinbin Xu, James M Noble, Sarah B Berman, Snezana Ikonomovic, Neelesh K Nadkarni, Gregory Day, Neill R Graff-Radford, Martin Farlow, Jasmeer P Chhatwal, Takeshi Ikeuchi, Kensaku Kasuga, Yoshiki Niimi, Edward D Huey, Stephen Salloway, Peter R Schofield, William S Brooks, Jacob A Bechara, Ralph Martins, Nick C Fox, David M Cash, Natalie S Ryan, Christoph Laske
Publication date
2024/5/1
Journal
The Lancet Neurology
Volume
23
Issue
5
Pages
500-510
Publisher
Elsevier
Description
Background
In people with genetic forms of Alzheimer's disease, such as in Down syndrome and autosomal-dominant Alzheimer's disease, pathological changes specific to Alzheimer's disease (ie, accumulation of amyloid and tau) occur in the brain at a young age, when comorbidities related to ageing are not present. Studies including these cohorts could, therefore, improve our understanding of the early pathogenesis of Alzheimer's disease and be useful when designing preventive interventions targeted at disease pathology or when planning clinical trials. We compared the magnitude, spatial extent, and temporal ordering of tau spread in people with Down syndrome and autosomal-dominant Alzheimer's disease.
Methods
In this cross-sectional observational study, we included participants (aged ≥25 years) from two cohort studies. First, we collected data from the Dominantly Inherited Alzheimer's Network studies …
Total citations
20241
Scholar articles
JK Wisch, NS McKay, AH Boerwinkle, J Kennedy… - The Lancet Neurology, 2024